Pseudoduplication of fovea in a human eye.

gest it was more susceptible to the effects of prostaglandins than the surrounding facial skin. We propose 2 hypothetical mechanisms for this. First, postinflammatory changes within the skin graft tissue could predispose it to hyperpigmentation as previously reported. Second, the graft tissue that came from the neck could be more susceptible than the surrounding facial skin to upregulation of the PGF2 receptor by UV light. We conclude that at-risk patients should be warned of the possibility of severe darkening of a facial skin graft from topical latanoprost and that the use of alternative topical ocular antihypertensive medications in these patients would be sensible.